Long shot but does killing the Midi utilities and rebooting and not opening them have any impact?
I'm thinking of a couple of possibilities. Midi communication having an impact or a memory leak of some sort related to that.
I'll give it a try. I have definitely tried running Wirecast alone and closing the Midi programs, but the issue is still there. I'll try to reboot and not open the apps at all. I'll let you know how it goes.
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