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MovieBuff
06-16-2014, 03:35 PM
This February, we first heard about a "bionic pancreas (http://www.gizmag.com/bionic-pancreas/30876/)" that could radically improve the lives of type 1 diabetics. At the time, multi-day trials involving groups of adult and adolescent patients were still yet to occur. Those trials have now taken place, and the results are definitely encouraging.

Being developed by scientists at Boston University and Massachusetts General Hospital, the bionic pancreas is made up of two externally-worn pumps, an app on an iPhone 4s, and a tiny sensor within a needle that's inserted under the skin. Every five minutes, that sensor monitors the glucose levels in the surrounding tissue fluid, and sends the readings to the app. If those levels get too high or too low, the app automatically triggers one or the other of the pumps to release either insulin or its counteracting hormone, glucagon, into the bloodstream.

Ordinarily, diabetics must monitor glucose levels themselves several times a day via fingerstick blood tests. If more insulin is required, it must be either manually injected or pumped into their body.

In the tests, a group of 20 adult diabetics used the bionic pancreas for five days while conducting their usual activities in downtown Boston, plus a group of 32 adolescents also tried them out over a five-day period at a youth camp. As a control, both groups were also monitored for a five-day period while only using their regular manual insulin pumps.

The device ended up working even better than expected. The adults required 37 percent less interventions for hypoglycemia (low blood glucose), while the youth experienced an almost-twofold reduction. Additionally, the adults saw a twofold reduction in the amount of time spent in a hypoglycemic state.

Larger multi-center trials are now planned to take place soon.

"A cure is always the end goal," said Boston University's Dr. Ed Damiano, whose own son has type 1 diabetes. "As that goal remains elusive, a truly automated technology, which can consistently and relentlessly keep people healthy and safe from harm of hypoglycemia, would lift an enormous emotional and practical burden from the shoulders of people with type 1 diabetes."

A paper on the research was published this week in the New England Journal of Medicine. (http://www.nejm.org/doi/full/10.1056/NEJMoa1314474)

Sources: National Institutes of Health (http://www.nih.gov/news/health/jun2014/niddk-15.htm), Massachusetts General Hospital (http://www.massgeneral.org/doctors/news/pressrelease.aspx?id=1715)


http://www.gizmag.com/bionic-pancreas-trials/32561/

mcphillips
06-16-2014, 04:32 PM
MovieBuff, are you diabetic?

MovieBuff
06-16-2014, 05:22 PM
MovieBuff, are you diabetic?

No, I know many who have diabetes though. Do you have diabetes?

digirhap
06-16-2014, 05:27 PM
Does seem like a lot of fanfare for something that has only been tested / got results from a group of 20 adults...

mcphillips
06-16-2014, 05:27 PM
Thankfully, no, but there are two Type 1's in my inner circle. One of the trials is being done 20 minutes from my home. I'm going to inquire as to whether one or both of these ladies might be able to participate.

MovieBuff
06-16-2014, 05:31 PM
No, I know many who have diabetes though. Do you have diabetes?

Absolutely, but it's still a small step in the right direction.


Thankfully, no, but there are two Type 1's in my inner circle. One of the trials is being done 20 minutes from my home. I'm going to inquire as to whether one or both of these ladies might be able to participate.

I hope it helps them.

mcphillips
06-16-2014, 06:00 PM
My son just told me that he's following research that Google is apparently doing. They are developing a sensor that will monitor blood glucose levels in real time without having to prick your finger many times per day.

MovieBuff
06-16-2014, 06:21 PM
My son just told me that he's following research that Google is apparently doing. They are developing a sensor that will monitor blood glucose levels in real time without having to prick your finger many times per day.

Your son is right: http://www.gizmag.com/google-smart-contact-lens-diabetes/30494/

mcphillips
06-17-2014, 04:36 AM
The comments at the bottom of the article are not too encouraging. The Echo (http://www.echotx.com/continuous-glucose-monitoring.shtml) system mentioned in the comments looks promising.

MovieBuff
10-13-2014, 10:43 AM
The comments at the bottom of the article are not too encouraging. The Echo (http://www.echotx.com/continuous-glucose-monitoring.shtml) system mentioned in the comments looks promising.

Here's another update:

Stem cell researchers at Harvard University have devised a method for creating large quantities of human insulin-producing beta cells, which could soon lead to a cure for type 1 diabetes as well as a new treatment for type 2 diabetes. The cells are currently being trialled in animals and non-human primates with hopes human trials could take place in the near future.

Source: http://www.gizmag.com/stem-cell-diabetes-cure-insulin-producing-beta-cells/34221/
Read the comments sections of the link.

MovieBuff
11-07-2014, 09:48 PM
http://youtu.be/De1NCk3hhqw

Source: http://www.gizmag.com/verapamil-diabetes-clinical-trial/34642/