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mcphillips
09-16-2013, 06:56 PM
The reason I spend hours each month helping people with their audio is because I enjoy doing it. Audio is a passion, and helping people is a passion. People have asked how to pay me. I don't charge.

However, there is a cause about which I'm very passionate. The Juvenile Diabetes Research Foundation is funding research for all sorts of ways to make life better for people with Type I diabetes. Some of my best friends are diabetic as is my son's fiance.

If you want to show me your appreciation for whatever little help I may have provided you, go to my friend Beth Knott's JDRF Walk for the Cure (http://www2.jdrf.org/site/TR?px=1410689&fr_id=2358&pg=personal) page and make a small donation. You can make it anonymously, if you wish. If you don't want to make a donation or you don't have a spare $5, that's fine, I'll still help. Your willingness to help JDRF is mutually exclusive from my willingness to help you with audio issues.

If this post is tacky, I'm sorry, but this organization is making a difference now. While the cure for juvenile diabetes may not be at hand, methods of improving the qualities of life of those afflicted with diabetes are at hand. It takes money. Thank you.

andrewzarian
09-16-2013, 07:11 PM
done and done. donated the other day :)

mcphillips
09-16-2013, 07:29 PM
Yes you did. The Internet broadcasting community has come through like champs. This post is to make sure that EVERYONE has an opportunity! :D

MovieBuff
02-07-2014, 07:25 AM
http://www.gizmag.com/pancreas-beta-cell-insulin-stem-cell/30754/


Type 1 diabetics suffer from a lack of beta cells in the pancreas, which are responsible for insulin production. Although glucose monitoring and insulin injections allows the disease to be managed, finding a way to replenish these beta cells would offer a more permanent solution. Scientists at Gladstone Institutes in San Francisco have provided hope for just such a treatment by developing a technique to reprogram skin cells into insulin-producing beta cells.

Because of their limited regenerative ability, researchers have had a hard time generating large quantities of beta cells. But now, thanks to stem cell technology, researchers in the lab of Gladstone Institutes' Investigator Sheng Ding, MD, PhD, have managed to transform skin cells into insulin-secreting beta cells.

The team started with skin cells responsible for the structural framework of animal tissues known as fibroblasts, which were collected from laboratory mice. By treating them with a cocktail of molecules and reprogramming factors, the fibroblasts were transformed into cells resembling endoderm cells, which are cells found in very early embryos that eventually mature into the body's major organs, including the pancreas.

"Using another chemical cocktail, we then transformed these endoderm-like cells into cells that mimicked early pancreas-like cells, which we called PPLC’s," said Gladstone Postdoctoral Scholar Ke Li, PhD. "Our initial goal was to see whether we could coax these PPLC’s to mature into cells that, like beta cells, respond to the correct chemical signals and – most importantly – secrete insulin. And our initial experiments, performed in a petri dish, revealed that they did."

When the researchers then transplanted PPLC's into mice that had been modified to have hyperglycemia, which is a key indicator of diabetes, the same thing happened, and one week after the transplant, the animal's glucose levels started to drop and gradually approach normal levels. When the transplanted cells were removed, the researchers saw an immediate spike in glucose levels.

Even more promising, when the team tested the mice eight weeks after the transplantation of the cells, they saw that the PPLC's had led to the rise of functional, insulin-secreting beta cells.

"I am particularly excited about the prospect of translating these findings to the human system," said Matthias Hebrok, PhD, who is one of the study’s authors and director of the UCSF Diabetes Center. "Most immediately, this technology in human cells could significantly advance our understanding of how inherent defects in beta cells result in diabetes, bringing us notably closer to a much-needed cure."

The team's study is published in the journal Cell Stem Cell (http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2814%2900007-1).

Source: Gladstone Institutes (http://gladstoneinstitutes.org/node/11467)
(Quick (http://www.gizmag.com/pancreas-beta-cell-insulin-stem-cell/30754/))

Donovan
02-07-2014, 04:54 PM
Since this thread was bumped today, it was the first time I saw it. I gave what I could. :)